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3,5-DIMETHYL-3-CYCLOHEXENE-1-CARBALDEHYDE.

Questionable CAS 68039-48-5 / PERFUMING

A synthetic aldehyde fragrance component that delivers a distinctive floral, leafy aroma reminiscent of ivy. While effective at enhancing product sensory experience, it carries notable allergenicity concerns that require careful formulation consideration. European regulatory bodies classify it as a sensitizing allergen requiring mandatory label disclosure above specific thresholds.

perfuming

Science

Functions purely as an olfactory modifier without direct therapeutic action on skin cells. The aldehyde structure interacts with olfactory receptors to create fragrance perception, while its sensitization potential arises from hapten formation through skin protein binding.


Research

Medium confidence
Effective range ≤0.02%
Optimal

N/A

Key findings

  1. 01 Patch testing at 5% concentration showed 2.8% positive allergic reactions in 106 patients
  2. 02 SCCS analysis indicates concentrations up to 0.02% demonstrate low sensitization induction potential

Transparency

Not commonly dusted
Red flag below
0.02%

Regulatory restrictions and allergenicity concerns prevent meaningful dusting above 0.02% maximum threshold


The Formula

Solubility
Oil
Optimal pH 4 – 8
0 7 14

Stability

Vulnerable to oxidative degradation and hydrolytic breakdown in water-based systems. Requires antioxidant protection or microencapsulation for enhanced stability.

Synergies

  • Antioxidants like BHT
  • Microencapsulation systems

Conflicts

  • Strong oxidizing agents
  • Strong acids
  • Strong bases
  • Primary amines

Safety

CIR Status
Not reviewed
Max tested
0.02%
Sensitization risk High

Must be declared on labels if exceeding 0.001% in leave-on products or 0.01% in rinse-off formulations. IFRA restricts usage based on NESIL value of 5900 μg/cm².


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Questionable

While effective for fragrance applications, significant allergenicity concerns and strict regulatory limitations make this ingredient challenging for precision skincare formulations.


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