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3,5,6-TRIMETHYL-3-CYCLOHEXENYL-4-PENTEN-3-ONE.

Questionable CAS 67801-32-5 / PERFUMING

A cyclic ketone fragrance compound from the ionone family that serves as an olfactory masking agent in cosmetic formulations. This hydrophobic ingredient provides sensory enhancement but offers no documented skin health benefits beyond fragrance modulation.

perfuming

Science

Functions exclusively as a perfuming agent through olfactory masking and sensory modification. Provides no bio-active mechanisms for skin improvement, barrier repair, or anti-aging effects.


Research

Medium confidence
Effective range ≤2.5%
Optimal

N/A

Key findings

  1. 01 Human patch testing revealed irritation in 2 of 205 subjects (0.98% incidence rate) with erythema development but no sensitization reactions

Transparency

Not commonly dusted

Used primarily for fragrance purposes at low concentrations, not typically subject to dusting practices


The Formula

Solubility
Oil
Optimal pH 4 – 9
0 7 14

Stability

Demonstrates excellent stability across typical cosmetic pH ranges with high hydrophobicity (logP ~2.53). Requires oil phase or solubilizing agents for incorporation. Vulnerable to degradation under extreme oxidative conditions.

Conflicts

  • Nitrosating agents
  • Strong oxidizing agents

Safety

CIR Status
Not reviewed
Max tested
2.5%
Sensitization risk Low

Classified as Category 2 skin irritant by industrial assessments. EU regulations permit up to 2.5% in leave-on products with purity restrictions regarding nitrosamine contamination.


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Questionable

A fragrance-only ingredient with moderate irritation potential that provides no skin health benefits while carrying sensitization risks for sensitive skin types.


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