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3,4-DIHYDROXYBENZOYL DIPEPTIDE-49 AMIDE.

Insufficient Data / HUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

A sophisticated synthetic peptide that combines protocatechuic acid's antioxidant prowess with dipeptide signaling technology. This dual-action molecule targets oxidative stress while simultaneously enhancing skin barrier function and resilience. The unique amide-terminated structure optimizes stability and bioavailability in topical formulations.

humectant skin conditioning emollient skin protecting antioxidant

Science

The protocatechuic acid moiety neutralizes free radicals and reduces inflammatory markers, while the dipeptide-49 component activates cellular repair pathways and enhances moisture retention. This synergistic approach strengthens the skin's natural defense mechanisms against environmental stressors while promoting barrier recovery.


Research

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Dipeptide-49 derivatives demonstrate measurable reduction in skin sensitivity and enhanced barrier resilience

Transparency

Not commonly dusted

As a specialized peptide with limited usage data, dusting patterns are not well-established in the market


The Formula

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

Requires careful pH control and antioxidant protection due to phenolic group sensitivity to oxidation and alkaline degradation

Synergies

  • chelating agents
  • complementary antioxidants

Conflicts

  • strong oxidizing agents
  • highly alkaline ingredients
  • transition metal ions

Safety

CIR Status
Not reviewed
Sensitization risk Unknown

EU CosIng and PCPC INCI approved; individual components have established safety profiles for topical use


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Insufficient Data

Promising dual-action peptide with sound theoretical basis but lacks robust clinical validation for definitive recommendations.


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