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3,4-DIHYDROXYBENZOIC ACID.

Valuable CAS 99-50-3 / SKIN PROTECTING

3,4-Dihydroxybenzoic acid, also known as protocatechuic acid, is a phenolic compound that demonstrates multi-pathway anti-aging efficacy through collagen stimulation and metalloproteinase inhibition. This water-soluble antioxidant effectively targets photoaging while providing measurable wrinkle reduction at concentrations as low as 0.02%.

antioxidant skin-brightening soothing anti-aging

Science

Functions as a potent free radical scavenger while simultaneously inhibiting Matrix Metalloproteinase-1 (MMP-1) expression triggered by UV radiation and environmental pollutants. Stimulates Type I procollagen synthesis for structural support and suppresses tyrosinase activity to reduce melanogenesis and promote skin brightening.


Research

High confidence
Effective range 0.02–10%
Optimal

0.02%

Key findings

  1. 01 Significant reduction in crow's feet wrinkles through enhanced collagen synthesis and MMP-1 inhibition
  2. 02 No significant irritation or toxicity in cumulative testing on 30 healthy adults

Transparency

Not commonly dusted

Effective at very low concentrations (0.02%), making dusting unlikely to be a concern for this ingredient.


The Formula

Solubility
Water
Optimal pH 3 – 6.6
0 7 14

Stability

Requires acidic to slightly acidic pH range for optimal stability. Vulnerable to oxidation and discoloration when exposed to air or alkaline conditions.

Conflicts

  • Strong bases
  • Strong oxidizing agents
  • Alkaline environments (pH > 7.0)

Safety

CIR Status
Not reviewed by CIR
Max tested
10%
Sensitization risk Low

Recognized as a safe metabolite of CIR-approved parabens and FDA-approved as food flavoring adjuvant. Pure crystalline form classified as irritant by GHS, but cosmetic concentrations are well-tolerated.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

A clinically-proven, low-concentration anti-aging ingredient with excellent safety profile and multi-pathway efficacy for photoaging prevention.


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References