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3,4-DIETHOXYBENZALDEHYDE.

Optional CAS 2029-94-9 / PERFUMING

A synthetic aromatic aldehyde structurally related to vanillin, primarily utilized for fragrance applications in skincare formulations. Research suggests potential anti-inflammatory and DNA-protective properties, though its primary function remains as a scent component with moderate skin compatibility considerations.

fragrance potential anti-inflammatory agent

Science

Functions primarily as a fragrance molecule while potentially inhibiting pro-inflammatory cytokine release (particularly IL-12) and reducing macrophage activation. May offer DNA protection by interfering with mutagenic damage pathways, though this mechanism requires further validation in human skin models.


Research

Low confidence
Effective range 0.1–1%
Optimal

0.5%

Key findings

  1. 01 Bacterial assays demonstrated 42-91% reduction in mutation frequency at concentrations of 0.1-1.0%
  2. 02 Patent literature indicates anti-inflammatory potential for UV-induced skin damage treatment

Transparency

Not commonly dusted

Insufficient market data available for dusting analysis of this specialized fragrance ingredient


The Formula

Solubility
Oil
Optimal pH 4 – 7
0 7 14

Stability

Demonstrates excellent stability under controlled conditions but requires protection from air and light exposure to prevent oxidation to 3,4-diethoxybenzoic acid. Nitrogen storage recommended for optimal preservation.

Conflicts

  • Strong oxidizing agents
  • Strong bases
  • Direct sunlight exposure

Safety

CIR Status
Not reviewed
Max tested
0.5%
Sensitization risk Moderate

Classification as GHS Category 2 skin and eye irritant in pure form. Safety assessment based on parent compound benzaldehyde, which is approved up to 0.5% in fragrance applications.


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Optional

A specialized fragrance ingredient with intriguing but preliminary anti-inflammatory research that requires careful formulation due to moderate irritation potential.


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