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3,4-DIAMINOBENZOIC ACID.

Avoid CAS 619-05-6 / HAIR DYEING

3,4-Diaminobenzoic acid is a specialized aromatic compound primarily utilized as an intermediate in hair dye chemistry and pharmaceutical synthesis. While it demonstrates proton scavenging activity and high diphenolase activity in laboratory settings, its application in general skincare remains largely unexplored and potentially problematic.

hair dyeing pharmaceutical intermediate

Science

Functions as a proton scavenger and exhibits diphenolase activity, participating in redox reactions and cyclocondensation processes to form benzimidazole compounds, though these mechanisms are primarily relevant for hair dye synthesis rather than direct skin benefits.


Research

Low confidence
Effective range ≤0.2%
Optimal

N/A

Key findings

  1. 01 Safety validation limited to hair dye formulations only, with no assessment for leave-on skincare applications

Transparency

Not commonly dusted

Not commonly used in skincare formulations due to safety restrictions and lack of proven skin benefits


The Formula

Solubility
Water
Optimal pH 4.5 – 5.5
0 7 14

Stability

Requires storage in dark, inert atmospheres to prevent oxidation; exhibits amphoteric behavior due to dual amine and carboxyl functional groups

Conflicts

  • Strong oxidizing agents
  • Strong acids
  • Isocyanates

Safety

CIR Status
Safe with restrictions
Max tested
0.2%
Sensitization risk High

Approved only for hair dye applications under 0.2%; classified as skin and strong eye irritant with no safety data for leave-on skincare use


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Avoid

Inappropriate for skincare applications due to irritation potential and lack of safety data for leave-on use.


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