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3,3,5-TRIMETHYLCYCLOHEXYL SUCCINATE DIMETHYLAMIDE.

Valuable CAS 1449076-27-0 / SKIN CONDITIONING

A synthetic active ingredient engineered to boost cellular proteasome activity by 150%, enhancing the skin's natural ability to degrade damaged proteins and clear cellular debris. This oil-soluble compound functions as a cellular detoxification enhancer, protecting against environmental stressors including visible light and pollution while reducing signs of aging.

skin conditioning antioxidant detoxifying anti-aging

Science

Functions as a proteasome activity booster, enhancing the cellular machinery responsible for breaking down damaged and misfolded proteins. By accelerating this natural detoxification pathway, it prevents the accumulation of protein aggregates that contribute to cellular aging and environmental damage.


Research

High confidence
Effective range 0.1–1%
Optimal

0.5%

Key findings

  1. 01 At 0.5% concentration, demonstrated significant reduction in skin surface roughness and visible wrinkle fading with 150% proteasomal activity enhancement
  2. 02 At 0.1-1.0% range, provided protection against visible light-induced pigmentation through enhanced cellular defense mechanisms

Transparency

Not commonly dusted
Min. effective
0.1%
Red flag below
0.05%

Effective concentrations start at 0.1%, making dusting below this level ineffective for cellular detoxification benefits


The Formula

Solubility
Oil
Optimal pH 4 – 8
0 7 14

Stability

Liquid at room temperature, stable in both O/W and W/O emulsions. Compatible with glycol and alcohol-based systems.

Synergies

  • antioxidants
  • peptides
  • niacinamide

Safety

CIR Status
Not reviewed
Max tested
2%
Sensitization risk Low

IECIC listed for China. Typically used at 0.1-1.0% in global formulations with good safety profile.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Valuable

A scientifically-backed cellular detoxification enhancer with proven efficacy at reasonable concentrations, particularly valuable for urban skincare and anti-aging formulations.


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