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Moumoujus

2-OLEAMIDO-1,3-OCTADECANEDIOL.

Valuable CAS 54422-45-6 / SKIN CONDITIONING

A synthetic pseudo-ceramide that functions as a barrier repair specialist, mimicking the natural lipid architecture of healthy skin. This ceramide precursor integrates into the skin's intercellular matrix to restore compromised barrier function and reduce water loss. Its dual role as both an immediate barrier enhancer and a building block for endogenous ceramide synthesis makes it particularly effective for damaged or sensitive skin conditions.

Summary

skin-identical ingredient moisturizer conditioning agent barrier repair

Science

Mechanism of Action

Functions as a biomimetic lipid that integrates into the stratum corneum's intercellular lamellae, filling structural gaps in the skin barrier. Acts as a metabolic precursor that the skin converts into longer-chain ceramides like Ceramide 1, while simultaneously reducing transepidermal water loss and strengthening defense against environmental irritants.

Research

Clinical Evidence

High confidence
Effective range 0.2–0.7%
Optimal

0.2%

Key findings

  1. 01 Maximum effective concentration for leave-on facial products to restore lipid bilayer integrity
  2. 02 Highest safe concentration in rinse-off hair treatments for structural conditioning

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.05%
Red flag below
0.01%

Given its lipophilic nature and specialized barrier repair function, concentrations below 0.05% are unlikely to provide meaningful barrier restoration benefits. Trace amounts under 0.01% suggest cosmetic dusting rather than therapeutic intent.

The Formula

Formulation

Solubility
Oil
Optimal pH 4 – 9
0 7 14

Stability

Extremely lipophilic compound requiring specialized emulsification systems for water-based formulas. Remains stable across physiological pH ranges but may exhibit cloudiness in highly acidic environments below pH 4.0.

Synergies

  • lecithin
  • cholesterol
  • other ceramides
  • fatty acids

Conflicts

  • high-shear processing without proper carriers
  • purely aqueous systems without emulsification

Safety

Safety Profile

CIR Status
Safe as used
Max tested
0.2%
Pregnancy
Safe
Sensitization risk Low

Approved for use up to 0.2% in leave-on products and 0.7% in rinse-off applications. Expected to remain localized in the epidermis without systemic absorption concerns.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

A scientifically-backed barrier repair ingredient that delivers measurable improvements in skin barrier function when used at appropriate concentrations.

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