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2-OLEAMIDO-1,3,4-OCTADECATRIYL PROLINATE.

Valuable CAS 1319128-52-3 / ANTI-SEBORRHEIC, ANTI-SEBUM, HAIR CONDITIONING, SKIN CONDITIONING

A synthetic pseudoceramide that combines lipid and amino acid structures to mimic the skin's natural barrier components. This advanced ingredient reinforces the epidermal barrier while providing dual benefits of hydration and sebum regulation across all skin types.

Skin conditioning Barrier repair Anti-seborrheic Firming

Science

Functions as a ceramide analog that integrates into the lipid bilayer structure of the stratum corneum, strengthening barrier integrity and reducing transepidermal water loss. Simultaneously stimulates fibroblast activity to support collagen synthesis while regulating sebaceous gland activity through anti-seborrheic mechanisms.


Research

Medium confidence
Effective range 0.5–2%
Optimal

1%

Key findings

  1. 01 Enhanced skin barrier repair and firmness when formulated in patented complexes, with demonstrated improvements in skin lifting and hydration parameters

Transparency

Not commonly dusted

Typically used at meaningful concentrations (0.5-2.0%) as part of functional complexes rather than trace amounts


The Formula

Solubility
Oil
Optimal pH 4 – 7
0 7 14

Stability

Demonstrates excellent stability in anhydrous formulations and oil-in-water emulsions within standard cosmetic pH ranges, with hydrolysis susceptibility at pH extremes

Synergies

  • Other ceramides
  • Barrier lipids
  • Moisturizing agents

Conflicts

  • Strong oxidizing agents
  • Extreme pH conditions

Safety

CIR Status
Not reviewed
Sensitization risk Low

Approved by EU Cosing database and FDA for cosmetic use with established safety profile in premium dermatological formulations


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

A sophisticated pseudoceramide that delivers proven barrier repair and sebum regulation benefits across all skin types with excellent safety profile.


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