2-NITRO-N-HYDROXYETHYL-P-ANISIDINE

2-NITRO-N-HYDROXYETHYL-P-ANISIDINE.

Questionable CAS 57524-53-5 / HAIR DYEING

A specialized nitro-aromatic compound primarily designed for hair coloring applications, functioning as a direct dye through physical deposition into hair cuticles. While regulated as safe for hair dyeing at concentrations up to 1%, this ingredient offers no established skincare benefits and serves only as a colorant in cosmetic formulations. Its minimal systemic absorption (0.22% of applied dose) demonstrates low penetration through skin barriers.

Colorant Hair dyeing agent

Science

Mechanism of Action

Functions through direct physical deposition and diffusion into target substrates due to its small molecular size, without requiring chemical activation or coupling reactions for color development

Research

Clinical Evidence

Low confidence

Effective range N/A

Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Not applicable for skincare formulations as this ingredient provides no skin benefits

The Formula

Formulation

Solubility

Water

Optimal pH 7 – 9

0 7 14

Stability

Maintains stability in aqueous solutions for up to 7 days at 0.03% concentration. Material exhibits hygroscopic properties and may undergo color darkening during storage without purity loss.

Conflicts

Nitrosating agents (Sodium Nitrite, Bronopol)
Strong oxidizing agents
Strong acids

Safety

Safety Profile

CIR Status

Not reviewed

Max tested

Sensitization risk Low

Regulated under EU Cosmetics Regulation Annex III/198 with strict prohibition against use with nitrosating agents due to potential nitrosamine formation risks

Your Skin

Skin Compatibility

No Normal

No Dry

No Oily

No Sensitive

Irritancy Low

Comedogenicity Unknown

Our Assessment

Verdict

Questionable

Inappropriate for precision skincare applications as it provides no skin benefits and serves only as a hair coloring agent.

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References

Sources

europa.eu ↗