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2-METHOXY-4-METHOXYMETHYL-PHENOL.

Optional CAS 5533-03-9 / PERFUMING

A vanillin derivative primarily recognized for its fragrance and masking properties in cosmetic formulations. While laboratory studies suggest potential antioxidant benefits through free radical scavenging, clinical evidence for skin-specific therapeutic effects remains limited.

perfuming masking potential antioxidant

Science

Functions primarily as an olfactory modifier and masking agent through volatile aromatic interactions, with theoretical antioxidant activity via free radical neutralization and possible pro-inflammatory cytokine inhibition


Research

Low confidence
Effective range 0.1–1%
Optimal

N/A

Key findings

  1. 01 In vitro antioxidant and anti-inflammatory properties demonstrated, though peer-reviewed clinical trials for skin benefits are lacking

Transparency

Not commonly dusted

Primarily used as a functional fragrance component rather than an active ingredient, making dusting practices less relevant


The Formula

Solubility
Both
Optimal pH 4.5 – 6.5
0 7 14

Stability

Demonstrates moderate water solubility (6.9 g/L) and high oil solubility; vulnerable to oxidation under intense light or elevated temperatures due to phenolic structure

Conflicts

  • Strong oxidizing agents
  • Strong alkaline conditions (pH >7) leading to phenolate formation and potential discoloration

Safety

CIR Status
Not reviewed
Max tested
0.5%
Sensitization risk Low

RIFM safety assessment established NESIL of 3500 μg/cm²; GRAS status for flavor applications; primarily validated for cosmetic fragrance use


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Optional

A functional fragrance ingredient with theoretical antioxidant potential but insufficient clinical evidence to justify inclusion for therapeutic skin benefits.


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References