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Moumoujus

2-HYDROXYETHYLAMINO-5-NITROANISOLE.

Questionable CAS 66095-81-6 / HAIR DYEING

A synthetic nitro dye compound specifically developed for hair coloring applications that provides yellow-to-orange pigmentation. This direct-acting colorant works by penetrating the hair cuticle without requiring oxidative reactions, making it suitable for semi-permanent and temporary hair tinting formulations. While primarily designed for hair use, it has limited relevance in traditional skincare applications.

Summary

hair dyeing

Science

Mechanism of Action

Functions as a direct-acting colorant by diffusing into the hair cuticle through its small molecular size, where it deposits color without chemical oxidation reactions, adhering to hair surfaces to provide yellow-to-orange tones

Research

Clinical Evidence

Medium confidence
Effective range 0.2–0.2%
Optimal

0.2%

Key findings

  1. 01 SCCS safety evaluation confirmed acceptability for semi-permanent hair dye use with measured percutaneous absorption of 0.64% without hair and 0.29% with hair present

Transparency

Dusting Analysis

Not commonly dusted

Not applicable for skincare dusting as this ingredient is specifically regulated for hair dye applications only

The Formula

Formulation

Solubility
Water
Optimal pH 6.5 – 9.5
0 7 14

Stability

Demonstrates high stability in typical hair dye formulations but shows susceptibility to nitrosation when exposed to nitrites or nitrosating compounds

Conflicts

  • Nitrosating agents
  • Nitrites

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.2%
Sensitization risk Low

EU SCCS regulation limits use to 0.2% in non-oxidative hair dyes only. Secondary amine structure requires nitrosamine content below 50 ppb. Classified as slightly eye-irritating but non-irritating to skin.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

A specialized hair dye ingredient with no established skincare benefits and regulatory restrictions limiting its use to hair coloring applications only.

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