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2-ETHYL-4-HYDROXY-5-METHYLFURAN-3(2H)-ONE.

Optional CAS 27538-10-9 / PERFUMING

A furanone compound with demonstrated melanin-inhibiting properties comparable to established brightening agents like arbutin. This water-soluble ingredient offers dual-action depigmentation through both genetic and enzymatic pathways, while also functioning as a fragrance component in skincare formulations.

fragrance depigmenting agent antioxidant

Science

Operates through a comprehensive dual-inhibition approach to melanogenesis: suppresses tyrosinase gene transcription at the mRNA level while simultaneously blocking the catalytic activity of existing tyrosinase enzymes, effectively interrupting melanin synthesis at multiple stages.


Research

Medium confidence
Effective range ≤1%
Optimal

N/A

Key findings

  1. 01 In vitro melanoma cell studies showed melanin formation inhibition equivalent to arbutin through tyrosinase suppression

Transparency

Not commonly dusted

Primarily used as fragrance component rather than active ingredient, making dusting unlikely in brightening formulations


The Formula

Solubility
Water
Optimal pH 3 – 7
0 7 14

Stability

Extremely oxygen-sensitive requiring antioxidant stabilization systems and inert atmosphere storage below 15°C to prevent degradation

Conflicts

  • oxidizing agents
  • strong alkaline conditions
  • UV exposure

Safety

CIR Status
Not reviewed
Max tested
1%
Sensitization risk Low

IFRA fragrance safety limit of 1.0% established; FDA GRAS status for flavoring applications (FEMA 3623)


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Optional

Promising brightening potential but primarily relegated to fragrance applications due to significant formulation stability challenges.


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