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Moumoujus

2-DECENOL.

Questionable CAS 22104-80-9 / PERFUMING

2-Decenol is a fatty alcohol primarily recognized for its role as a penetration enhancer and fragrance component in skincare formulations. This lipophilic compound works by disrupting the skin's barrier structure to improve the delivery of other active ingredients. While it shows promise in research applications, its potential for irritation limits its use in sensitive skin formulations.

Summary

penetration enhancer fragrance masking agent

Science

Mechanism of Action

Functions as a penetration enhancer by disrupting the highly organized intercellular lipid lamellae in the stratum corneum, creating temporary pathways for improved active ingredient delivery while potentially modifying skin protein conformation

Research

Clinical Evidence

Low confidence
Effective range 0.01–3%
Optimal

N/A

Key findings

  1. 01 Research focused on antimicrobial properties in plant essential oils and penetration enhancement capabilities in topical delivery systems (0.01% - 3%)

Transparency

Dusting Analysis

Not commonly dusted

Primarily used as a functional penetration enhancer and fragrance component rather than a marketing-driven active ingredient

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Highly lipophilic (LogP ~3.69) with limited water solubility (204.8 mg/L); remains stable as clear colorless liquid under standard storage conditions; soluble in alcohols and oils

Conflicts

  • strong oxidizing agents

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
3%
Sensitization risk Moderate

Classified as skin and eye irritant (GHS Category 2) in pure form; approved for fragrance use up to 3%; holds FEMA GRAS status (No. 4304) for food flavoring

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

While effective as a penetration enhancer, the moderate irritation potential and limited clinical validation make it a questionable choice for most consumer skincare applications.

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