Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

2-CHLORO-5-NITRO-N-HYDROXYETHYL-P-PHENYLENEDIAMINE.

Avoid CAS 50610-28-1 / HAIR DYEING

A specialized nitro-substituted aromatic amine that serves as a primary intermediate in oxidative hair coloring systems. This compound penetrates hair cortex due to its small molecular size and undergoes radical oxidation reactions to create permanent color molecules. While primarily designed for hair applications, it represents a potent chemical dyeing agent with specific safety considerations.

Summary

hair dyeing oxidative coupling agent direct dye intermediate

Science

Mechanism of Action

Functions through oxidative coupling reactions where it diffuses into hair cortex and reacts with hydrogen peroxide and alkalizers to form large, trapped pigment molecules that provide permanent coloration

Research

Clinical Evidence

Medium confidence
Effective range 2.5–4.6%
Optimal

4.6%

Key findings

  1. 01 Rabbit patch testing at 2.5% showed no irritation over 72 hours on intact and abraded skin
  2. 02 Guinea pig studies demonstrated safety at 3.0% with daily application for 5 consecutive days
  3. 03 SCCS evaluation confirms safety up to 4.6% in oxidative formulations for eye area use

Transparency

Dusting Analysis

Not commonly dusted

Not applicable for skincare formulations as this ingredient is exclusively used in hair dyeing applications

The Formula

Formulation

Solubility
Water
Optimal pH 2 – 11.5
0 7 14

Stability

Requires acidic pH (2.0-3.0) for storage stability and alkaline pH (9.0-11.0) for activation. Light-sensitive and requires cool storage to prevent premature oxidation.

Synergies

  • Hydrogen peroxide (oxidizing agent)
  • Alkalizing agents for activation

Conflicts

  • Nitrosating agents
  • Strong oxidizing agents outside controlled conditions
  • Metal ions and catalytic metals

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
4.6%
Pregnancy
Caution
Sensitization risk High

Belongs to phenylenediamine group with known sensitization potential. SCCS evaluations support safety in hair applications with restrictions. Not intended for direct skin contact applications.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Specialized hair dyeing agent inappropriate for skincare applications due to sensitization risks and lack of skin benefits.

Related

Similar Ingredients

Finding similar ingredients…