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2-AMINO-4-NITROPHENOL SULFATE.

Questionable CAS 89418-01-9 / HAIR DYEING

A synthetic aromatic compound primarily developed for hair coloring applications, specifically designed to produce golden-blonde tones in oxidative dye systems. This water-soluble ingredient functions through direct binding mechanisms with keratin proteins, though its dermal penetration remains minimal under standard formulation conditions.

hair dyeing color coupling

Science

Operates through direct molecular binding to keratin structures, creating stable color complexes without requiring traditional oxidative activation pathways for its primary effects


Research

Medium confidence
Effective range 0.5–1.54%
Optimal

1.5%

Key findings

  1. 01 Demonstrated minimal dermal penetration (0.21-0.36%) in controlled absorption studies using carboxymethylcellulose vehicle systems
  2. 02 Showed non-irritating properties in standardized rabbit irritation protocols using propylene glycol carriers

Transparency

Not commonly dusted

Primarily utilized in specialized hair care applications rather than general skincare formulations, reducing likelihood of concentration manipulation


The Formula

Solubility
Water
Optimal pH 7 – 9.5
0 7 14

Stability

Maintains structural integrity within alkaline pH environments and withstands hydrogen peroxide exposure; requires protection from light exposure and oxygen-free storage conditions

Synergies

  • hydrogen peroxide
  • carboxymethylcellulose

Conflicts

  • acids
  • acid chlorides
  • acid anhydrides
  • chloroformates
  • strong oxidizing agents
  • iron

Safety

CIR Status
Safe as used
Max tested
1.5%
Sensitization risk Low

Regulatory approval limited to hair treatment applications with specific cautions regarding N-nitroso compound formation potential


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Questionable

Specialized hair dye component with limited skincare applications and restricted regulatory approval for cosmetic use.


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