Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle

2-AMINO-3-HYDROXYPYRIDINE.

Questionable CAS 16867-03-1 / HAIR DYEING

2-Amino-3-hydroxypyridine is a synthetic compound primarily engineered as a coupling agent in oxidative hair dye systems. While extensively studied for hair coloring applications, this ingredient lacks established skincare benefits and demonstrates limited skin penetration (0.306% absorption over 48 hours).

hair dyeing color coupling agent

Science

Functions as a reactive coupling agent that combines with primary intermediates in the presence of oxidizing agents to form colored pigment molecules. Does not exhibit documented skincare mechanisms such as anti-aging, hydration, or barrier repair properties.


Research

Medium confidence
Effective range ≤1%
Optimal

N/A

Key findings

  1. 01 CIR 2014: Non-sensitizing at 50% concentration in ethanol:water vehicle
  2. 02 SCCS 2014: Safe at maximum 1.0% concentration with minimal percutaneous absorption
  3. 03 CIR 2014: Non-irritating to skin at 100% concentration but causes eye irritation

Transparency

Not commonly dusted

Not applicable for skincare formulations as this ingredient is specifically designed for hair dye applications


The Formula

Solubility
Water
Optimal pH 1.5 – 9
0 7 14

Stability

Demonstrates high stability under standard temperature and pressure conditions. Enhanced solubility in polar solvents due to hydrogen bonding capacity.

Conflicts

  • Strong oxidizing agents
  • Strong acids
  • Acid chlorides
  • Acid anhydrides
  • Nitrosating agents

Safety

CIR Status
Safe with restrictions
Max tested
1%
Sensitization risk Low

Approved for hair dye use only with mandatory patch testing requirements. Classified as coal tar hair dye requiring caution labeling in US regulations.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Questionable

Inappropriate for precision skincare as it lacks dermatological benefits and is specifically formulated for hair dye applications.


Related

Finding similar ingredients…