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Moumoujus

2-ACETYLHYDROQUINONE.

Questionable CAS 490-78-8 / ANTIOXIDANT, BLEACHING, SKIN CONDITIONING

A synthetic antioxidant and brightening agent that offers similar benefits to hydroquinone without the same safety concerns. This dual-action compound targets inflammation and pigmentation through precise molecular pathways. Despite its efficacy potential, it remains controversial due to structural similarities to hydroquinone.

Summary

antioxidant skin brightening anti-inflammatory skin conditioning

Science

Mechanism of Action

Functions by suppressing inducible Nitric Oxide Synthase (iNOS) expression and blocking ERK1/2 and NF-κB inflammatory signaling pathways, while simultaneously neutralizing oxidative species that trigger melanin production for brightening effects.

Research

Clinical Evidence

Medium confidence
Effective range 0.1–5%
Optimal

2.5%

Key findings

  1. 01 Patent literature demonstrates effectiveness at 0.1-5% for inhibiting inflammatory cytokines TNF-α and IL-6
  2. 02 Industrial applications at 100-4,000 ppm show high stability and antioxidant potency

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.5%
Red flag below
1%

Often included at minimal concentrations for marketing claims despite requiring higher percentages for meaningful antioxidant and brightening effects

The Formula

Formulation

Solubility
Both
Optimal pH 4.5 – 6
0 7 14

Stability

Maintains stability under standard storage but degrades rapidly when exposed to strong oxidizing conditions or alkaline environments

Synergies

  • vitamin C
  • niacinamide
  • kojic acid

Conflicts

  • Strong oxidizing agents
  • Strong bases
  • Alkaline reagents

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
5%
Pregnancy
Caution
Sensitization risk Moderate

Classified as skin and eye irritant in concentrated forms; avoided by major retailers due to hydroquinone structural similarity despite being a distinct compound

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

While scientifically promising as an antioxidant and brightening agent, market stigma and moderate irritation potential limit its practical application in precision skincare.

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