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Moumoujus

2,6-XYLENOL.

Questionable CAS 576-26-1 / PERFUMING

A phenolic compound primarily utilized as a fragrance component in cosmetic formulations. While it demonstrates non-sensitizing properties at low concentrations in laboratory testing, its high irritancy potential and corrosive nature at higher concentrations raise formulation concerns.

Summary

perfuming

Science

Mechanism of Action

Functions primarily as a perfuming agent, with secondary biological activity involving prostaglandin E2 synthesis inhibition at 0.1 μmol concentrations, potentially contributing to anti-inflammatory effects.

Research

Clinical Evidence

Medium confidence
Effective range 0.01–0.05%
Optimal

0.05%

Key findings

  1. 01 Demonstrated non-sensitizing properties in Guinea Pig Maximization Tests and Local Lymph Node Assays when used below dermal sensitization threshold

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.05%
Red flag below
0.1%

Given its high irritancy rating and corrosive properties, concentrations exceeding 0.05% present significant safety concerns

The Formula

Formulation

Solubility
Both
Optimal pH 6 – 7
0 7 14

Stability

Demonstrates stability under standard conditions with pKa of 10.59. Limited water solubility (6-10 g/L) but excellent ethanol compatibility. Highly flammable material requiring careful handling.

Conflicts

  • Oxidizing agents
  • Acid chlorides
  • Acid anhydrides
  • Bases
  • Steel
  • Copper and copper alloys

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.05%
Sensitization risk Low

RIFM and IFRA guidelines establish 0.05% maximum usage in fragrance applications. Pure compound classified as H314 corrosive with significant toxicity at industrial concentrations.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

While technically non-sensitizing at regulated concentrations, the high irritancy potential and narrow safety margin make this ingredient problematic for precision skincare applications.

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