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Moumoujus

2,5-DIMETHYLPYRAZINE.

Insufficient Data CAS 123-32-0 / PERFUMING

A volatile pyrazine compound that functions as a TRPM5 receptor agonist, showing promising dual action in melanogenesis enhancement and cellular senescence management. While traditionally used as a fragrance ingredient at low concentrations, emerging research reveals potential anti-aging properties through senolytic activity.

Summary

Fragrance Flavoring agent Potential pigmentation enhancer Experimental senolytic agent

Science

Mechanism of Action

Activates TRPM5 channels to stimulate tyrosinase activity and melanin synthesis while demonstrating senolytic effects that selectively target and eliminate aged senescent cells contributing to skin deterioration.

Research

Clinical Evidence

Medium confidence
Effective range ≥0.0014%
Optimal

N/A

Key findings

  1. 01 12.5 mM topical application increased epidermal melanin content and tyrosinase activity in human skin organ culture after 72 hours
  2. 02 Demonstrated senolytic effects in comparative human skin research studies

Transparency

Dusting Analysis

Not commonly dusted

Primarily used as fragrance component at very low concentrations (0.0014%), not typically used for cosmetic dusting

The Formula

Formulation

Solubility
Both
Optimal pH 5 – 7
0 7 14

Stability

Highly volatile with tendency to evaporate; maintains stability at physiological pH range but degrades under extreme conditions

Conflicts

  • Strong oxidizing agents
  • Strong acids

Safety

Safety Profile

CIR Status
Not reviewed as skincare ingredient
Max tested
0.0014%
Sensitization risk Low

RIFM-assessed for fragrance use and FDA GRAS-approved for food applications; safety data limited for skincare concentrations above fragrance levels

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Intriguing dual-mechanism ingredient with preliminary anti-aging research, but limited safety data for skincare concentrations beyond fragrance use.

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