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2,5-DIHYDROXYBENZOYL DIPEPTIDE-48.

Valuable / HUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

A dual-function synthetic peptide that combines gentisic acid with dipeptide technology to enhance ingredient delivery while providing brightening benefits. This advanced compound acts as both a penetration enhancer and skin-conditioning agent, making it particularly effective in high-performance formulations.

humectant skin conditioning emollient skin protecting penetration enhancer

Science

Functions through a dual mechanism: the gentisic acid component inhibits tyrosinase enzyme activity to reduce melanin production, while the dipeptide structure provides humectant properties and enhances transepidermal delivery of co-formulated actives. In proprietary complexes, it creates molecular channels that increase absorption speed and depth by over 2-fold.


Research

Medium confidence
Effective range ≥0.1%
Optimal

0.1%

Key findings

  1. 01 3D Raman spectroscopy study showed 2.13x increase in absorption speed and depth at 0.1% concentration
  2. 02 Clinical trial on 20 subjects demonstrated 47.55% improvement in skin radiance with immediate visible clarity enhancement

Transparency

Not commonly dusted

Specialized peptide ingredient typically used at effective concentrations due to cost and specific functionality requirements


The Formula

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

Maintains stability in slightly acidic to neutral pH environments. Heat resistance improves when combined with high molecular weight polymeric humectants.

Synergies

  • High molecular weight PEG
  • Other peptides
  • Vitamin C derivatives

Conflicts

  • Strong oxidizing agents
  • Highly acidic formulations (pH < 4)
  • Highly alkaline formulations (pH > 8)

Safety

CIR Status
Not reviewed
Sensitization risk Low

Recognized as safe humectant and skin conditioner in EU Cosmetic Ingredient Glossary without specific restrictions


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

A sophisticated dual-purpose peptide with proven enhancement capabilities and excellent safety profile across all skin types.


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