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2,5,6-TRIAMINO-4-PYRIMIDINOL SULFATE.

Avoid CAS 1603-02-7 / HAIR DYEING

A chemical precursor compound designed specifically for oxidative hair coloring systems that creates permanent pigmentation through chemical reaction with hydrogen peroxide. This ingredient serves no established function in skincare formulations and carries notable safety concerns including skin sensitization potential.

hair dyeing

Science

Acts as a developer in oxidative hair dye systems by penetrating hair shafts and reacting with coupling agents under alkaline conditions to form large, stable pigment molecules within the hair cortex


Research

High confidence
Effective range ≤0.5%
Optimal

N/A

Key findings

  1. 01 SCCS safety assessment at 0.5% concentration in hair dye formulations (SCCS/1561/15)
  2. 02 Rat toxicity study establishing NOAEL at 200 mg/kg body weight daily (SCCP/1122/07)

Transparency

Not commonly dusted
Red flag below
0.01%

This hair dye precursor has no legitimate use in skincare products and should raise immediate red flags if found in facial or body care formulations


The Formula

Solubility
Water
Optimal pH 7 – 10
0 7 14

Stability

Extremely unstable compound with 24-hour aqueous stability limit, requires antioxidant protection and strict light/moisture exclusion

Conflicts

  • Oxidizing agents
  • Strong acids
  • Light exposure
  • Moisture

Safety

CIR Status
Not reviewed
Max tested
0.5%
Pregnancy
Caution
Sensitization risk High

EU-regulated substance with GHS warnings for skin sensitization, eye irritation, and oral toxicity; kidney abnormalities observed at high doses in animal studies


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Avoid

A hair dye ingredient with no skincare benefits and significant safety concerns that has no place in precision skincare formulations.


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