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Moumoujus

2,4-HEXADIENAL.

Avoid CAS 142-83-6 / PERFUMING

An unsaturated aldehyde compound that occasionally appears as a trace component in cosmetic formulations, primarily from lipid oxidation or as a fragrance residue. This reactive molecule functions as a direct-acting alkylating agent that binds to cellular proteins and DNA, creating significant safety concerns for topical use.

Summary

perfuming flavoring

Science

Mechanism of Action

Acts as a potent skin sensitizer by binding covalently to skin proteins through haptenization, triggering immune responses. Simultaneously depletes cellular glutathione while forming DNA adducts and inducing strand breaks through its alkylating properties.

Research

Clinical Evidence

High confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted
Red flag below
0.001%

Any detectable presence should be flagged as this ingredient is prohibited for intentional cosmetic use and appears only as unwanted contamination or oxidation byproduct

The Formula

Formulation

Solubility
Oil
Optimal pH 4 – 7
0 7 14

Stability

Extremely unstable with tendency toward autopolymerization and oxidation. Requires cold storage (2-8°C) and antioxidant stabilization with compounds like alpha-tocopherol at 0.5%. Light and temperature sensitive.

Conflicts

  • Strong oxidizing agents
  • Strong bases
  • Reducing agents
  • Primary amines

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.001%
Pregnancy
Caution
Sensitization risk High

Prohibited by IFRA for fragrance use. Listed under California Proposition 65 as carcinogen with clear evidence of carcinogenic activity identified by National Toxicology Program in animal studies.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

A prohibited ingredient with established carcinogenic and sensitization risks that should never be intentionally included in skincare formulations.

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