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Moumoujus

2,3-XYLENOL.

Questionable CAS 526-75-0 / PERFUMING

2,3-Xylenol is a phenolic compound primarily utilized as a fragrance component in cosmetic formulations, contributing a distinctive musty or phenolic scent profile. While it demonstrates interaction with skin thermosensation channels, its primary cosmetic application remains limited to perfuming functions rather than active skincare benefits.

Summary

perfuming

Science

Mechanism of Action

Functions predominantly as a scent modifier through olfactory interaction. Additionally acts as a TRPV3 channel agonist in skin cells, potentially influencing thermosensation and barrier function pathways, though this mechanism is not leveraged for cosmetic benefits.

Research

Clinical Evidence

Low confidence
Effective range ≤0.02%
Optimal

0.02%

Key findings

  1. 01 Maximum recommended usage concentration for fragrance applications to maintain safety margins and minimize irritation potential

Transparency

Dusting Analysis

Not commonly dusted
Red flag below
0.02%

Not typically used for ingredient list enhancement due to its primary industrial applications and high irritation potential at concentrations above 0.02%

The Formula

Formulation

Solubility
Both
Optimal pH ≤10.5
0 7 14

Stability

Maintains stability for 24 hours in aqueous, DMSO, and ethanol systems under standard laboratory conditions. Solubility increases significantly in alkaline environments due to phenolate formation at pH above 10.5.

Conflicts

  • Bases
  • Acid chlorides
  • Acid anhydrides
  • Oxidizing agents
  • Steel
  • Brass
  • Copper

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.02%
Sensitization risk High

Regulated under IFRA fragrance standards rather than CIR review. Classified as GHS Category 3 toxic in pure form and demonstrates corrosive properties at elevated concentrations.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

Limited to fragrance applications with significant irritation concerns and no demonstrated skincare benefits.

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