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2,2'-METHYLENEBIS-4-AMINOPHENOL HCL.

Avoid CAS 27311-52-0 / HAIR DYEING

A synthetic chemical compound primarily designed for hair dyeing applications, functioning as an oxidative coupler that forms colored pigments. While technically skin-contact occurs during hair treatments, this ingredient lacks established skincare benefits and is not formulated for cosmetic skin applications. Its primary role involves chemical reactions under alkaline conditions rather than therapeutic skin effects.

Hair dye intermediate Oxidative coupler

Science

Functions through oxidative coupling reactions in alkaline environments, forming large pigment molecules when combined with hydrogen peroxide and other intermediates. Does not provide direct skincare benefits like moisturization or anti-aging effects, as its mechanism targets hair cortex penetration rather than skin improvement.


Research

Medium confidence
Effective range ≤1%
Optimal

N/A

Key findings

  1. 01 SCCS safety evaluation established 1.0% maximum safe concentration for scalp contact
  2. 02 Rabbit irritation testing at 6% aqueous solution showed non-irritating properties over 72 hours

Transparency

Not commonly dusted
Red flag below
1%

Not appropriate for skincare dusting as it's a hair dye intermediate with no established cosmetic benefits and regulatory restrictions above 1.0%


The Formula

Solubility
Water
Optimal pH 6.9 – 9.5
0 7 14

Stability

Exceptional water solubility at 164 g/L but requires careful handling due to oxidation sensitivity. Solutions degrade rapidly and need daily preparation. Powder form remains stable when stored in darkness at ambient temperature.

Conflicts

  • Strong oxidizing agents
  • Light exposure
  • Metal ions

Safety

CIR Status
Not reviewed
Max tested
1%
Sensitization risk High

EU-regulated under Annex III/248 with strict concentration limits. Classified as skin sensitizer requiring caution in formulation.



Our Assessment

Avoid

Hair dye ingredient with no skincare benefits and sensitization risks that make it inappropriate for precision skincare formulations.


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References