2,2'-METHYLENEBIS-4-AMINOPHENOL

2,2'-METHYLENEBIS-4-AMINOPHENOL.

Avoid CAS 63969-46-0 / HAIR DYEING

A chemical intermediate primarily designed for hair dyeing applications that functions through oxidative coupling reactions. While extensively studied for safety in cosmetic products, this compound lacks documented benefits for skincare applications and carries notable sensitization concerns. Its primary regulatory oversight focuses on hair dye formulations rather than leave-on skincare products.

colorant hair dye intermediate

Science

Mechanism of Action

Functions as an oxidative developer that reacts with hydrogen peroxide and coupler molecules to form larger pigment compounds, but possesses no established therapeutic mechanisms for skin health improvement

Research

Clinical Evidence

Low confidence

Effective range N/A

Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Red flag below

0.5%

Rarely used in skincare formulations due to lack of skin benefits and safety concerns; any presence above 0.5% suggests formulation error or inappropriate application

The Formula

Formulation

Solubility

Water

Optimal pH 3 – 4

0 7 14

Stability

Requires acidic conditions around pH 3.2 for stability; rapidly degrades in alkaline environments causing brown-black discoloration; solutions require fresh preparation

Conflicts

hydrogen peroxide
alkaline pH adjusters
metal-containing ingredients
oxidizing preservatives

Safety

Safety Profile

CIR Status

Safe with restrictions

Max tested

Pregnancy

Caution

Sensitization risk High

EU-restricted to maximum 1.0% concentration; classified as potential skin sensitizer with scrutinized genotoxic potential; primarily regulated for hair applications

Our Assessment

Verdict

Avoid

An inappropriate ingredient for skincare applications with high sensitization risk and no documented skin benefits.

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References

Sources