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Moumoujus

2-(2-AMINOETHOXY)ETHANOL.

Valuable CAS 929-06-6 / HAIR FIXING

A multifunctional alkanolamine compound that serves as a penetration enhancer and solvent system in skincare formulations. This ingredient increases the bioavailability of active compounds like vitamin C and benzoyl peroxide by facilitating their transport through the stratum corneum barrier. At regulated concentrations below 2.6%, it functions as both a delivery optimizer and pH buffering agent.

Summary

solvent buffering penetration enhancer

Science

Mechanism of Action

Works by disrupting and fluidizing the lipid bilayer structure of the stratum corneum, creating temporary pathways that allow both hydrophilic and lipophilic actives to penetrate more effectively. Additionally functions as an alkaline buffering system to neutralize acidic formulation components and maintain optimal pH stability.

Research

Clinical Evidence

High confidence
Effective range 1–10%
Optimal

2.6%

Key findings

  1. 01 Demonstrated enhanced penetration and bioavailability of vitamin C, DHA, and benzoyl peroxide through increased solubility and stratum corneum partitioning
  2. 02 SCCS evaluation confirmed safety for leave-on applications with anti-aging and moisturizing benefits

Transparency

Dusting Analysis

Not commonly dusted

Not applicable as this is a functional penetration enhancer used at specific concentrations for efficacy rather than marketing purposes

The Formula

Formulation

Solubility
Water
Optimal pH 8 – 11
0 7 14

Stability

Exhibits high stability in alkaline environments and acts as a hygroscopic liquid. Shows increased reactivity compared to diethanolamine due to primary amine functionality

Synergies

  • Vitamin C
  • Benzoyl Peroxide
  • DHA
  • Acidic actives requiring pH buffering

Conflicts

  • Nitrosating agents
  • Strong oxidizing compounds
  • Acids
  • Isocyanates
  • Halogenated organics
  • Peroxides

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
2.6%
Sensitization risk Moderate

SCCS restricts leave-on cosmetic use to maximum 2.6% concentration due to irritation potential at higher levels. Classified as corrosive in undiluted form. Must avoid combination with nitrosating agents to prevent nitrosamine formation

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Low

Our Assessment

Verdict

Valuable

A scientifically-backed penetration enhancer that significantly improves active ingredient delivery when used within safety-established concentration limits.

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References

Sources