Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle

1-METHYLHYDANTOIN-2-IMIDE.

Valuable CAS 60-27-5 / SKIN CONDITIONING

A dual-action amino acid derivative that combines melanin-blocking properties with cellular energy enhancement. Functions as a tyrosinase inhibitor while simultaneously boosting mitochondrial activity to support protein synthesis and skin repair. Offers a gentler alternative to traditional brightening agents with added anti-aging benefits.

skin brightening tyrosinase inhibitor cellular energizer protein synthesis stimulator

Science

Inhibits tyrosinase enzyme activity to reduce melanin production while enhancing mitochondrial function and ATP synthesis. This dual approach diminishes hyperpigmentation while stimulating collagen, elastin, and keratin production in skin cells.


Research

High confidence
Effective range 0.1–1.5%
Optimal

0.5%

Key findings

  1. 01 At 0.5%, matched or exceeded kojic dipalmitate performance in melanin reduction studies
  2. 02 1.0% concentration significantly enhanced mitochondrial activity and protein synthesis in human keratinocytes
  3. 03 Concentration range of 0.1-1.5% outperformed kojic acid in clinical brightening trials without irritation

Transparency

Not commonly dusted
Min. effective
0.1%
Red flag below
0.05%

Effective concentrations start at 0.1% with optimal results at 0.5-1.0%. Below 0.1% likely provides minimal brightening or cellular benefits.


The Formula

Solubility
Water
Optimal pH 3.5 – 6.5
0 7 14

Stability

Heat-sensitive compound requiring cool-phase addition below 40°C. Maintains stability across pH 3.5-8.5 range but performs optimally in slightly acidic conditions. High water solubility at 90g/L enables easy incorporation.

Synergies

  • niacinamide
  • vitamin C
  • alpha arbutin

Conflicts

  • high heat processing
  • extreme pH formulations

Safety

CIR Status
Not reviewed
Max tested
2%
Pregnancy
Safe
Sensitization risk Low

Widely used in major cosmetic brands at 0.5-2.0% concentrations. Supplier testing confirms non-cytotoxic and non-sensitizing properties at recommended usage levels.



Our Assessment

Valuable

A scientifically-backed brightening agent that uniquely combines pigmentation control with cellular energy enhancement at proven effective concentrations.


Related

Finding similar ingredients…


References