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Moumoujus

1,5-PENTANEDIOL.

Valuable CAS 111-29-5 / SOLVENT

1,5-Pentanediol is a multifunctional organic compound valued in precision skincare for its hydrating, solvent, and antimicrobial properties. It actively draws moisture to the skin, enhances formulation stability, and significantly improves the penetration of other active ingredients.

Summary

humectant solvent antimicrobial penetration enhancer

Science

Mechanism of Action

This diol acts as a powerful humectant, attracting and binding water molecules from the environment to the skin, thereby sustaining optimal hydration and preventing moisture depletion. It also functions as an effective solvent, dissolving and stabilizing active compounds within cosmetic formulations to ensure their uniform distribution and enhanced bioavailability. Furthermore, 1,5-Pentanediol exhibits antimicrobial effects against a spectrum of bacteria, fungi, and viruses, likely through cellular dehydration, and is noted for its ability to boost the percutaneous absorption of co-formulated ingredients.

Research

Clinical Evidence

High confidence
Effective range 2.5–25%
Optimal

25%

Key findings

  1. 01 Used in a gel formulation for the prophylactic evaluation of herpes labialis, applied at 0.04g/day over a 26-week period.
  2. 02 When combined with 1% hydrocortisone in a cream and applied twice daily for 6 weeks, it led to a statistically significant reduction in *Staphylococcus aureus* in patients with atopic dermatitis.
  3. 03 Demonstrated minimal inhibitory concentrations (MIC) against 85 diverse bacterial strains, encompassing both antibiotic-susceptible and multi-resistant Gram-positive and Gram-negative bacteria, in in vitro studies.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

1,5-Pentanediol exhibits robust chemical stability under recommended storage conditions, contributing positively to product shelf-life and performance. However, formulators should be aware of reports indicating its potential to compromise the stability of certain cream formulations.

Synergies

  • Enhances penetration of active ingredients

Conflicts

  • Strong oxidizing agents

Safety

Safety Profile

CIR Status
Safe as used
Max tested
25%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has rigorously assessed 1,5-Pentanediol, concluding its safety for use in cosmetics within current practices and concentrations, including topical formulations up to 25%. It demonstrates low acute toxicity across all exposure routes and is not considered an irritant or sensitizer.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

1,5-Pentanediol is a valuable ingredient due to its multifaceted benefits as a powerful humectant, effective solvent, broad-spectrum antimicrobial, and penetration enhancer, all while maintaining an excellent safety and compatibility profile across all skin types.

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