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Moumoujus

1,4-CYCLOHEXANEDICARBOXYLIC ACID.

Valuable CAS 1076-97-7 / NOT REPORTED

1,4-Cyclohexanedicarboxylic Acid is a specialized ingredient engineered to enhance the delivery of other active compounds into the skin. It functions by temporarily and reversibly modifying the skin's barrier, thereby improving the absorption of actives that typically have low affinity with the stratum corneum.

Summary

Skin absorption enhancer

Science

Mechanism of Action

This ingredient operates as a targeted skin absorption enhancer. Its mechanism involves a gentle and reversible weakening of the stratum corneum's barrier function, which subsequently boosts the penetration of active ingredients that might otherwise struggle to absorb. This enhancement is reported to occur without inducing skin irritation or damage.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The compound exhibits robust hydrolytic and excellent thermal stability, distinguishing it from certain other dicarboxylic acids. It maintains stability under normal temperatures and pressures. Proper storage in tightly sealed containers, away from moisture or contaminants in a cool, dry, and well-ventilated environment, is recommended.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) has not conducted a specific safety assessment for 1,4-Cyclohexanedicarboxylic Acid in cosmetic use. It is not currently listed as a prohibited or restricted cosmetic ingredient by the FDA, though it is recognized as a food contact substance with a Cumulative Estimated Daily Intake (CEDI) of 0.8 µg/kg bw/d. While GHS classifications for the raw substance indicate potential for skin irritation (Category 2, H315) and serious eye irritation (Category 2, H319), a patent asserts that its application as a skin absorption enhancer does not lead to irritation or damage, differentiating it from other dicarboxylic acids.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

1,4-Cyclohexanedicarboxylic Acid offers valuable potential as a permeation enhancer, capable of optimizing the delivery and efficacy of other active ingredients in skin care formulations, though more independent clinical and safety data are anticipated for a comprehensive assessment.

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