Science
Mechanism of Action
Alloferon-1 enhances NK cell activity and interferon synthesis while suppressing pro-inflammatory cytokines in UVB-exposed keratinocytes. Zinc further modulates immune defense, provides anti-inflammatory and antioxidant actions, and supports wound healing and keratinocyte processes, with the complex demonstrating enhanced thermodynamic stability.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Kuczer et al., 2010
- 02 Chernysh et al., cited in Kuczer et al., 2010
- 03 Kim et al., 2013
Transparency
Dusting Analysis
There is no information suggesting that ZINC S-ALLOFERON-1 is commonly used in concentrations too low to be effective.
The Formula
Formulation
Stability
The Zinc(II) complex with Alloferon-1 exhibits enhanced thermodynamic stability due to its unique histamine-like binding mode. Optimal stability and activity are observed between pH 7.0-7.5.
Safety
Safety Profile
Alloferon is characterized as non-cytotoxic and non-immunogenic. While many zinc salts are deemed safe by CIR, a specific safety assessment for the ZINC S-ALLOFERON-1 complex itself is currently unavailable.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This ingredient shows promising immunomodulatory and anti-inflammatory properties; however, further specific safety and efficacy data for its topical application are required for a conclusive rating.
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References
Sources