Science
Mechanism of Action
This sesquiterpene acts as an anti-inflammatory by potentially reducing inflammatory markers and as an antioxidant by scavenging reactive oxygen species. Zederone also exhibits antibacterial activity, contributing to a multi-faceted approach against skin concerns.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 Low cytotoxicity of 75 µg/mL zederone towards normal peripheral blood mononuclear cells (PBMCs) when tested against KG1a cells.
- 02 Related anti-inflammatory sesquiterpenes (furanodiene and furanodienone at 1.0 micromol) from Curcuma zedoaria suppressed TPA-induced inflammation of mouse ears by 75% and 53% respectively.
Transparency
Dusting Analysis
There is no information available to suggest Zederone is commonly dusted in cosmetic formulations.
The Formula
Formulation
Safety
Safety Profile
Zederone demonstrated hepatotoxicity and an LD50 of 223 mg/kg BW (intraperitoneal) in mice, along with moderate inhibition of human CYP2B6 and CYP3A4 enzymes in vitro. Its cosmetic safety for topical use is not established, and it is not recommended for fragrance or flavor applications.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Despite potential anti-inflammatory and antioxidant properties, Zederone presents significant systemic toxicity concerns, making its use in topical formulations highly unadvisable without extensive safety data.
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References
Sources