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Ingredient directory

Xyloglucan

Xyloglucan is a plant-derived polysaccharide known for its mucin-like structure, enabling it to form a protective barrier on skin and mucous membranes. It is beneficial for moisturizing, supporting the epidermal barrier, and promoting skin regeneration.

Directory entry · Individual source review pending

This profile is awaiting an individual source review. Treat its ratings, dose estimates and compatibility labels as provisional; they are not medical advice or proof of a finished product’s effects.

Skin protectant Skin-conditioning agent Film former Moisturizer Barrier support Anti-inflammatory Skin regeneration

Science

Mechanism of Action

It forms a protective, mucoadhesive barrier on the skin, reducing permeability and preventing bacterial adherence. It supports the epidermal barrier by preserving lipid content, preventing TEWL, and moisturizing, while also promoting keratinocyte and fibroblast proliferation for regeneration.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 PMC, MDPI (dry eye syndrome)
  2. 02 JCAD (atopic dermatitis)
  3. 03 PMC, MDPI (skin regeneration)

Transparency

Dusting Analysis

Not commonly dusted

There is no available data to suggest that xyloglucan is commonly dusted in skincare formulations.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Xyloglucan is highly water-soluble, forming colloidal dispersions, and exhibits broad pH tolerance. Degalactosylated forms can create thermosensitive hydrogels up to 5%.

Synergies

  • Pea proteins (for atopic dermatitis treatment)

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
5%
Sensitization risk Low

Approved by the FDA as a food additive (GRAS up to 5%) and excipient for drug delivery. It is a biocompatible, biodegradable, nonionic polysaccharide with demonstrated optimal tolerability in clinical trials.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Xyloglucan is a valuable ingredient for its barrier-supporting, moisturizing, anti-inflammatory, and regenerative properties, with a strong safety profile.

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References

Sources

Keep exploring

From ingredients to everyday care.

Sensitive skin ↗

Start with comfort, product choices and the questions to ask.

Barrier support ↗

Understand moisture, lipids and the limits of ingredient claims.

Ingredient names help you read a label. They do not establish how a finished product will perform. Explore The Garden.