Science
Mechanism of Action
This extract exerts anti-inflammatory effects by inhibiting COX-2, IL-1β, TNF-α, NF-κB, and Lipoxygenase pathways. Rich in flavonoids, it acts as a potent antioxidant, scavenging various free radicals and offering antibacterial properties.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Methanol extract showed COX-2 inhibitory activity at 20 µg/mL (in vitro).
- 02 Waltheria extract significantly decreased IL-1β and TNF-α stimulated by LPS at 0.9-4.5 µg/mL (in vitro).
- 03 Aqueous extract showed DPPH radical inhibition with an IC50 of 79.5 µg/mL.
- 04 Ethanol leaf extract inhibited Bacillus cereus at 400 mg/mL and Staphylococcus aureus at 600 mg/mL.
Transparency
Dusting Analysis
No data suggests this ingredient is commonly included in formulations at sub-efficacious levels for marketing purposes.
The Formula
Formulation
Safety
Safety Profile
Toxicity studies in animals indicate a tolerable safety profile (LD50 300-5000 mg/kg), though high doses may be hepatotoxic. Topical pregnancy/breastfeeding data is limited, and a patch test is recommended due to uncommon, low risk of irritation.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Waltheria Indica Leaf Extract is a valuable multi-functional ingredient, offering robust anti-inflammatory, antioxidant, and skin-conditioning benefits with a low risk of irritation for various skin types.
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References
Sources