Science
Mechanism of Action
It scavenges free radicals, inhibits oxidative stress, and reduces pro-inflammatory cytokine expression. The extract diminishes melanin production by inhibiting tyrosinase and downregulating melanogenesis-related proteins, while also promoting collagen and offering UV protection.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Animal studies demonstrated potent anti-inflammatory effects, showing superior activity to aspirin at higher doses.
- 02 In vitro studies inhibited oxidative stress, tyrosinase activity, and α-MSH-induced melanin production without cytotoxicity.
- 03 Optimal extraction yielded 87.27% tyrosinase inhibitory activity, with specific stilbene oligomers surpassing kojic acid.
Transparency
Dusting Analysis
No specific data indicates that Vitis amurensis root extract is commonly dusted in formulations.
The Formula
Formulation
Stability
The extract's compounds vary in polarity, allowing extraction in both water and organic solvents. Optimal pH for stability is not specified, but related grape extracts are stable across typical cosmetic pH ranges.
Safety
Safety Profile
No specific CIR or FDA status exists, though related Vitis vinifera root extracts are generally considered safe. In vitro tests showed no remarkable cytotoxicity at concentrations up to 200 µg/mL.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Shows promising antioxidant, brightening, and anti-aging potential, but further human topical studies and safety assessments are needed for a conclusive recommendation.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources