Science
Mechanism of Action
This fruit oil and its compounds act by inhibiting pro-inflammatory pathways like NF-κB and MAPK, reducing nitric oxide and cytokine production. It also demonstrates antioxidant activity and potential for tyrosinase inhibition and estrogenic effects.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 Compounds from Vitex rotundifolia inhibit nitric oxide production in vitro (11.3-100 µM).
- 02 Extracts suppressed iNOS/COX-2 expression and IL-8 production in mouse macrophages and human cells in vitro.
- 03 Essential oil showed estrogenic activity on MCF-7 cells in vitro.
Transparency
Dusting Analysis
As a fruit oil, it is typically used as an emollient or active ingredient, and not subject to 'dusting' concerns related to minimal active concentrations.
The Formula
Formulation
Stability
Optimal pH for stability is not specified. As a fruit oil, it is typically oil-soluble and integrates into the oil phase of formulations.
Safety
Safety Profile
No specific CIR or SCCS assessments are available for this ingredient. While Vitex rotundifolia leaf oil is considered generally safe, a patch test is advised for sensitive skin.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While exhibiting promising in vitro anti-inflammatory and antioxidant properties, human clinical efficacy and comprehensive safety profiles for topical application remain unreviewed, warranting further research.
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References
Sources