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Moumoujus

UREASE.

Avoid CAS 9002-13-5 / VISCOSITY CONTROLLING

Urease is an enzyme catalyzing the hydrolysis of urea into carbon dioxide and ammonia. On the skin, its activity would break down beneficial urea, a natural moisturizing factor.

Summary

Science

Mechanism of Action

This enzymatic action converts urea into alkaline ammonia, consequently increasing the local pH of the skin environment. This can potentially disrupt the skin's natural acidic mantle.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 6 – 7.4
0 7 14

Stability

Urease activity is optimal between pH 7.0-7.4 and stable at pH 6.0, but denatures above 45 °C. Its action generates ammonia, which raises pH and can compromise pH-dependent preservatives.

Conflicts

  • 2-mercaptoethanol
  • acetohydroxamate
  • EDTA
  • phosphoramidate
  • fluoride ion
  • 1,4-benzoquinone
  • 2,5-dimethyl-1,4-benzoquinone

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

Urease is designated for R&D use only and is not assessed for cosmetic application by CIR, SCCS, or FDA. It is noted to cause skin and serious eye irritation, and may induce allergy or asthma symptoms if inhaled.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Urease activity on skin breaks down beneficial urea into irritant ammonia, increases pH, and is explicitly labeled for R&D use only with known irritancy and allergy risks.

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