Science
Mechanism of Action
This extract operates through its 'secretome,' a diverse collection of secreted proteins, growth factors (including GDF-11, EGF, FGF-2, KGF, PDGF, HGF, TGF-β1, Wnt7a), and cytokines. These components collectively drive skin regeneration and repair by promoting the proliferation and migration of fibroblasts and keratinocytes. It actively boosts the production of essential extracellular matrix components such as collagen (types 1 and 3) and elastin, leading to improved skin firmness, elasticity, and a reduction in wrinkles. Furthermore, it exhibits significant anti-inflammatory actions by modulating inflammatory cytokines like TNF-α, IL-1β, and IL-6, while increasing IL-10. It also offers antioxidant protection against oxidative stress, supports angiogenesis for wound healing, strengthens the skin barrier, and can contribute to a more even skin tone by inhibiting melanin production.
Research
Clinical Evidence
Medium confidence10%
Key findings
- 01 A 4-week in vivo human study with 22 volunteers demonstrated that daily topical application of a 10% concentration (cryo-preserved Umbilical Cord Blood-derived Mesenchymal Stem Cells Conditioned Media) in a cream base increased dermal density by 2.46% and decreased skin wrinkles. No irritation, stinging, or adverse reactions were observed.
- 02 A product incorporating Human Umbilical Mesenchymal Stem Cell Conditioned Media (at 100,000 ppm) is designed for fundamental regeneration and growth of aging skin tissues, aiming to strengthen the epidermis and dermis for enhanced elasticity and volume.
Transparency
Dusting Analysis
No specific data available to suggest common dusting practices or thresholds for this ingredient.
The Formula
Formulation
Stability
Typically supplied as a cryo-dehydrated powder for reconstitution with a cosmetic base. Once mixed, it maintains stability for approximately one week under refrigerated conditions. Lyophilized exosome forms derived from umbilical cord mesenchymal stem cells are also available and are noted for not requiring special refrigeration for shipping or storage.
Safety
Safety Profile
While the FDA has approved cord blood stem cells for certain hematopoietic conditions, it has not reviewed this ingredient specifically for cosmetic pre-market approval. The FDA has issued warnings regarding unapproved umbilical cord products, particularly those containing live cells or making therapeutic claims. However, non-clinical safety evaluations of umbilical cord-derived mesenchymal stem cell-conditioned medium (UCMSC-CM) have demonstrated it to be a safe substance, passing tests for eye irritation, skin sensitization, photosensitization, phototoxicity, single/repeated dose toxicity, and genotoxicity. Neither the CIR nor the SCCS has published a specific review for this cosmetic ingredient.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Umbilical Cord Cell Extract is a valuable regenerative ingredient, supported by clinical data showing improvements in dermal density and wrinkle reduction, with a robust multi-action mechanism and a low sensitization risk for cosmetic applications.
Related
Similar Ingredients
Finding similar ingredients…