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Moumoujus

UFIPRAZOLE.

Avoid CAS 73590-85-9 / SKIN CONDITIONING

Ufiprazole, also known as Omeprazole sulfide, is primarily recognized as a pharmaceutical intermediate in the synthesis of gastric proton pump inhibitors. While a 'skin conditioning' function has been noted by one source, current research provides no specific mechanism or substantiating data for its efficacy on the skin.

Summary

Science

Mechanism of Action

Specific details regarding Ufiprazole's mechanism of action on the skin in a cosmetic context are currently unavailable. Its established biological function relates to the inhibition of gastric acid secretion, which is not relevant to dermatological applications.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH 10.4 – 11
0 7 14

Stability

Ufiprazole exhibits significant instability in acidic environments, akin to its related compounds omeprazole and esomeprazole. Optimal stability is observed within a narrow, highly alkaline pH range of 10.4 to 11.0, with rapid decomposition occurring below pH 7.8.

Conflicts

  • Low pH environments (below pH 7.8)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

Ufiprazole carries multiple GHS hazard statements, including H315 (Causes skin irritation), H317 (May cause an allergic skin reaction), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). It is categorized by the European Chemicals Agency (ECHA) as a Skin Irritant (category 2), Skin Sensitizer (category 1), Eye Irritant (category 2), and a Specific Target Organ Toxicity - Single Exposure (category 3).

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Given the absence of substantiated skin benefits, the high risk of irritation and sensitization, and severe formulation constraints due to pH instability, Ufiprazole is unsuitable for precision skincare formulations.

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