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Moumoujus

TULIPALIN B.

Questionable CAS 38965-80-9 / SKIN PROTECTING

Derived from tulip plants, Tulipalin B acts as a natural antimicrobial powerhouse, leveraging its inherent defense mechanism. This compound exhibits potent fungitoxic and antibacterial properties, presenting a compelling opportunity for precision skincare formulations targeting microbial imbalances.

Summary

Antifungal Antibacterial Antimicrobial

Science

Mechanism of Action

Tulipalin B exerts its antimicrobial action through direct fungitoxic effects and by specifically targeting bacterial MurA, a key enzyme critical for bacterial cell wall peptidoglycan synthesis. This mechanism effectively disrupts bacterial integrity, sharing similarities with the mode of action proposed for cnicin.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Studies indicated potent antifungal activity, with concentrations as low as 0.05 mM exhibiting inhibitory effects against *Fusarium oxysporum f. sp tulipae*.
  2. 02 Broader antifungal efficacy against most tested strains was observed at a concentration of 2.5 mM.
  3. 03 Research also highlighted significant antibacterial activity when compared to other structural analogues.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The potential for polymerization, where Tulipalin B acts as a tri-functional monomer, indicates a challenge for long-term formulation stability.

Conflicts

  • Potential for polymerization (acting as a tri-functional monomer)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

Tulipalin B is listed in the FDA Global Substance Registration System (GSRS). However, contact with the ingredient can trigger allergic reactions in humans, leading to 'tulip fingers'—a condition characterized by skin irritation and dermatitis. Despite this, it has been reported to be considerably less allergenic than Tulipalin A.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

Tulipalin B offers specific antimicrobial benefits against fungi and bacteria; however, its unreviewed safety status by CIR and known potential for contact sensitization necessitate a cautious approach in formulation.

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