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Moumoujus

TRISODIUM FRUCTOSE DIPHOSPHATE.

Valuable CAS 81028-91-3 / ANTIOXIDANT, CHELATING

Trisodium Fructose Diphosphate is a metabolic sugar derivative that functions as a potent antioxidant and chelating agent in topical applications. It actively supports the skin's natural defense systems, mitigating oxidative stress and preserving vital antioxidant enzymes against environmental aggressors, particularly UVB-induced damage.

Summary

Antioxidant Chelating Agent UVB Damage Protection Endogenous Antioxidant Preservation

Science

Mechanism of Action

Trisodium Fructose Diphosphate operates via a dual mechanism to safeguard skin integrity. Primarily, it functions as a robust antioxidant, neutralizing free radicals, and as a chelating agent, binding to pro-oxidative metal ions. By preserving the skin's endogenous antioxidant enzymes, such as catalase and glutathione, it effectively prevents the accumulation of carbonylated proteins, thereby attenuating UVB-induced oxidative skin damage. Its metabolic origin as a precursor in the glycolytic pathway may also contribute to cellular health.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

1%

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The material maintains stability under normal ambient and anticipated storage conditions. For optimal shelf-life, it should be protected from light and moisture, stored in a cool, dry place, and kept away from oxidizing agents. Long-term stability is confirmed for at least 2 years when stored at -20°C.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While Trisodium Fructose Diphosphate has not undergone direct review by the CIR, related ingredient families, including monosaccharides, disaccharides, fructose, and simple phosphoric acid salts, have been deemed safe for cosmetic use, provided formulations avoid skin irritation. A Safety Data Sheet indicates the substance does not meet criteria for GHS classification, is not acutely toxic, skin corrosive/irritant, or a sensitizer. However, caution is advised with the raw compound, as it may cause skin or eye irritation.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Trisodium Fructose Diphosphate presents as a valuable antioxidant and chelating ingredient, demonstrating significant potential in protecting skin from oxidative damage and preserving its natural defenses.

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