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Moumoujus

TRIS(N-HYDROXYPROPYL) HEXAHYDROTRIAZINE.

Avoid CAS 25254-50-6 / ANTIMICROBIAL

TRIS(N-HYDROXYPROPYL) HEXAHYDROTRIAZINE is an antimicrobial agent primarily recognized for its biocidal properties in industrial applications. Its mechanism involves the rapid release of formaldehyde in aqueous solutions, leading to significant concerns regarding irritation, sensitization, and carcinogenic potential.

Summary

Antimicrobial

Science

Mechanism of Action

This compound functions as a formaldehyde releaser, where the liberated formaldehyde is responsible for its broad-spectrum biocidal efficacy against bacteria and fungi. Its local irritant effects are attributed to both formaldehyde and 1-aminopropan-2-ol, which are highly irritating hydrolysis products.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Demonstrated biocidal action in water-miscible metal-working fluids.
  2. 02 Utilized in concentrated metal-working fluid formulations.

Transparency

Dusting Analysis

Not commonly dusted
Red flag below
1%

This ingredient is not a cosmetic active ingredient intended for 'dusting'. However, a 1% solution at pH 7 can release approximately 20% formaldehyde by weight, which is a significant safety red flag due to its irritant and carcinogenic properties.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Undergoes rapid hydrolysis in aqueous solutions, exhibiting a half-life of less than one hour. This degradation produces formaldehyde and 1-aminopropan-2-ol. The rate of hydrolysis and the resulting equilibrium concentrations of these breakdown products are dependent on the ingredient's concentration, ambient pH, and temperature.

Conflicts

  • Ingredients sensitive to formaldehyde
  • Ingredients sensitive to strong irritants (due to hydrolysis products)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

The substance is categorized as highly irritating to corrosive for both skin and eyes in rabbit studies and acts as a skin sensitizer in guinea pigs. It is classified as Carcinogen Category 2, primarily due to the rapid release of formaldehyde, which itself is designated Carcinogen Category 4. A 1% solution at pH 7 is capable of releasing approximately 20% formaldehyde by the ingredient's initial weight.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Given its classification as a carcinogen due to rapid formaldehyde release, severe irritancy to skin and eyes, and high potential for skin sensitization, TRIS(N-HYDROXYPROPYL) HEXAHYDROTRIAZINE is unequivocally unsuitable for all skincare formulations and should be avoided.

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