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Moumoujus

TRIS-HYDROXYMETHYLNITROMETHANE.

Avoid CAS 126-11-4 / ANTIMICROBIAL

TRIS-HYDROXYMETHYLNITROMETHANE functions primarily as an antimicrobial agent, specifically a bactericide and slimicide, and can also act as a viscosity controller in cosmetic formulations. However, it is identified as a skin sensitizer and can decompose to formaldehyde under specific environmental conditions.

Summary

Antimicrobial Preservative Viscosity Controlling

Science

Mechanism of Action

This compound primarily exerts its action through potent antimicrobial properties, effectively inhibiting bacterial and slime growth. In cosmetic applications, it additionally contributes to product rheology by influencing and stabilizing viscosity.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Information regarding dusting properties is not available.

The Formula

Formulation

Solubility
Water
Optimal pH 4.5 – 5
0 7 14

Stability

TRIS-HYDROXYMETHYLNITROMETHANE demonstrates stability exclusively under acidic conditions, with an optimal pH range around 4.5 to 5.0. Its hydrolysis half-life is significantly reduced at neutral or alkaline pH, being 3.4 days at pH 7 and 2.4 days at pH 9. Elevated temperatures above 49 °C or exposure to alkaline conditions induce decomposition, leading to the formation of formaldehyde.

Conflicts

  • Alkaline conditions (leading to formaldehyde formation)
  • Temperatures above 49 °C
  • Strong acids
  • Reducing agents
  • Oxidizing substances

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

The Cosmetic Ingredient Review (CIR) Expert Panel has not specifically evaluated TRIS-HYDROXYMETHYLNITROMETHANE for cosmetic use. It is listed on the EPA TSCA Inventory as a registered pesticide and is an FDA Food Contact Substance with a Cumulative Estimated Daily Intake (CEDI) of 0.07 µg/kg bw/d. A primary concern is its identification as a skin sensitizer, posing a notable risk for allergic reactions. Additionally, its decomposition to formaldehyde under certain conditions is a safety consideration.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Given its classification as a skin sensitizer, potential to release formaldehyde, and predominantly industrial applications, TRIS-HYDROXYMETHYLNITROMETHANE is not recommended for use in precision skincare formulations.

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