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Moumoujus

TRIPROPYLENE GLYCOL DIACRYLATE.

Avoid CAS 42978-66-5 / PLASTICISER

Tripropylene Glycol Diacrylate (TPGDA) is a difunctional acrylic monomer extensively used in industrial UV- and electron beam-curable applications. While it appears in trace amounts, approximately 0.01%, within certain cosmetic products, its unreacted form is recognized as a potent skin irritant and sensitizer. When fully polymerized, it can function as a film-forming agent or stabilizer.

Summary

Plasticiser Film-Forming Agent Stabilizer

Science

Mechanism of Action

As a difunctional acrylic monomer, TPGDA's primary mechanism involves free radical polymerization when exposed to UV or electron beam radiation, facilitating its role as a cross-linking agent in various material sciences. In cosmetic contexts, unreacted TPGDA acts directly as a skin irritant and sensitizer. Conversely, its fully reacted, polymerized form contributes to the structural integrity of formulations by forming films or providing stabilization.

Research

Clinical Evidence

High confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Tripropylene Glycol Diacrylate is a liquid monomer, not typically processed or encountered as a powder, therefore not subject to dusting considerations in product formulation or handling.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

This ingredient maintains chemical stability under typical ambient conditions. However, it is highly prone to hazardous polymerization when exposed to heat, contaminants, oxygen-free environments, free radicals, peroxides, or UV/direct sunlight. The consistent presence of stabilizers like MEHQ and HQ is essential. Containers require an air space, and storage in an oxygen-free atmosphere must be avoided. Shelf-life typically extends to around 6 months when inhibitor levels are rigorously maintained.

Conflicts

  • Oxidizing agents
  • Strong acids
  • Strong bases
  • Metal salts
  • Brass
  • Copper
  • Steel (all types and surface treatments)
  • Iron and iron salts

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

Tripropylene Glycol Diacrylate has not been specifically reviewed by the Cosmetic Ingredient Review (CIR) Expert Panel, distinguishing it from related glycols. It is recognized as a high-hazard ingredient capable of causing significant eye and skin irritation, and it acts as a strong skin sensitizer. While its presence in some cosmetic products is noted at very low levels (e.g., 0.01%), there is no established safe maximum cosmetic concentration for direct application. No specific SCCS opinion is available. Although listed on the FDA's Inventory of Effective Food Contact Substance Notifications, its explicit status for cosmetic use by the FDA is not defined. Animal studies have indicated potential for tumorigenesis with dermal exposure.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Given its documented high irritancy, significant sensitization potential, and evidence of tumorigenesis in animal studies, Tripropylene Glycol Diacrylate is strongly advised against for inclusion in Moumoujus's precision skincare formulations for direct topical application.

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