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TRIPROPYLENE GLYCOL ACRYLATE.

Avoid CAS 42978-66-5 / NAIL CONDITIONING

Tripropylene Glycol Acrylate, often referenced as Tripropylene Glycol Diacrylate (TPGDA), is a reactive monomer primarily utilized in industrial applications like coatings and adhesives. In certain personal care contexts, it functions as a film-forming agent and an emulsion stabilizer.

Summary

Film-forming agent Emulsion stabilizer

Science

Mechanism of Action

Operating as a reactive monomer, Tripropylene Glycol Acrylate contains acrylate groups that enable rapid polymerization upon UV or thermal initiation. This process leads to crosslinking, which enhances the mechanical properties of polymers. In personal care applications, this allows it to create a protective film on the skin, contributing to product longevity and water resistance, and to stabilize emulsions by maintaining ingredient dispersion.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Tripropylene Glycol Acrylate is highly light-sensitive and prone to hazardous polymerization when exposed to heat, contamination, an oxygen-free atmosphere, free radicals, peroxides, or inhibitor depletion. Optimal stability is maintained under cool (<15°C), dark conditions, and an inert atmosphere.

Conflicts

  • Light
  • Heat
  • Contamination
  • Oxygen-free atmosphere
  • Free radicals
  • Peroxides
  • Oxidizing agents
  • Strong acids
  • Strong bases
  • Brass
  • Copper
  • Steel
  • Iron
  • Iron salts
  • Moisture

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

The Cosmetic Ingredient Review (CIR) has not specifically evaluated Tripropylene Glycol Acrylate or Tripropylene Glycol Diacrylate for safety in cosmetic applications. While a review exists for 'Tripropylene Glycol' (not the acrylate form), its findings do not apply here. GHS classifications indicate it 'May cause an allergic skin reaction' (H317), 'Causes skin irritation' (H315), 'Causes serious eye irritation' (H319), and 'May cause respiratory irritation' (H335). Allergic contact dermatitis has been reported in workers. Furthermore, a study in mice suggested it induced skin tumors, indicating potential carcinogenicity at the site of contact in long-term exposure scenarios.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Due to significant safety concerns, including a high risk of irritation, allergic sensitization, and evidence of potential carcinogenicity in animal studies, Tripropylene Glycol Acrylate is not suitable for precision skincare formulations.

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