Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

TRIPEPTIDE-41.

Insufficient Data CAS - / SKIN CONDITIONING

Tripeptide-41, also known as CG-Lipoxin, is a synthetic peptide engineered to target adipose tissue. It primarily functions as a lipolytic signal, promoting the breakdown of lipids and potentially enhancing skin firmness and elasticity.

Summary

Promotes lipolysis Inhibits lipogenesis Accelerates lipid hydrolysis Enhances skin elasticity Supports tissue regeneration Reduces adipocyte proliferation Prevents cholesterol accumulation Activates NF-kB signaling pathway Supports skin firmness

Science

Mechanism of Action

This tripeptide acts as a lipolytic signal peptide, actively delaying lipid accumulation within adipocytes and encouraging their breakdown into fatty acids. Its mechanism involves blocking the pro-lipid accumulation action of linoleic acid. Furthermore, Tripeptide-41 activates the nuclear transcription factor NF-kB, which subsequently stimulates tumor necrosis factor α (TNFα) production to trigger lipolysis. It also reportedly reduces C/EBP, a factor critical for adipocyte differentiation, and elevates cyclic adenosine monophosphate (cAMP) levels in fat cells. Increased cAMP initiates triglyceride hydrolysis, converting triacylglycerides into glycerin and fatty acids, which are then released from adipocytes, leading to a reduction in fat cell size. Beyond its lipolytic actions, research indicates support for skin firmness and elasticity.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

5%

Transparency

Dusting Analysis

Commonly dusted

Given that Tripeptide-41 is typically supplied for 'research use only' and is 'not approved for medical, cosmetic, or therapeutic use in humans,' any claims of efficacy in cosmetic products should be viewed with caution. The limited clinical data from a single manufacturer's study on a very small sample size makes it susceptible to being 'dusted' in formulations, implying its inclusion might be more for marketing claims rather than proven efficacy at relevant concentrations.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Tripeptide-41 exhibits excellent solubility and stability in aqueous systems, dissolving readily in sterile water or buffer. It has been incorporated into formulations at a pH of 6. For optimal long-term stability, it should be stored tightly sealed and desiccated at -20°C.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Specific safety assessments by regulatory bodies such as CIR, SCCS, or FDA are currently unavailable for Tripeptide-41. However, in research applications, it has demonstrated low cytotoxicity and good biocompatibility, with no significant adverse effects reported in cell culture or in-vitro skin model studies. It is important to note that this ingredient is generally supplied for research use only and lacks approval for medical, cosmetic, or therapeutic use in humans.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While Tripeptide-41 presents a promising mechanism for lipolysis and skin elasticity in laboratory settings, the critical lack of robust, independent human clinical data and regulatory approval for cosmetic use warrants a cautious approach.

Related

Similar Ingredients

Finding similar ingredients…