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Moumoujus

TRIPEPTIDE-36.

Insufficient Data CAS - / SKIN CONDITIONING

TRIPEPTIDE-36 refers to a three-amino acid peptide, for which direct, extensive cosmetic research is currently limited. The most prominent data is associated with its lipo-modified derivative, Palmitoyl Tripeptide-36, which demonstrates dual action as a potent antimicrobial and a skin regenerating signal peptide.

Summary

Antimicrobial Skin Regeneration Anti-Aging Supports Skin Firmness Improves Skin Elasticity Hydration (via Hyaluronic Acid stimulation) Wound Healing

Science

Mechanism of Action

While specific research on TRIPEPTIDE-36's direct mechanism is scarce, general tripeptide science suggests it can act as a signal messenger, penetrating superficial skin layers to stimulate vital processes. These include encouraging collagen and hyaluronic acid synthesis, promoting cellular repair, activating fibroblasts for tissue regeneration, and supporting angiogenesis. For its derivative, Palmitoyl Tripeptide-36, the mechanism is better defined: as a synthetic amphiphilic lipo-peptide, it forms micelle-like structures that disrupt negatively charged bacterial and fungal membranes, leading to cell death and exhibiting antimicrobial activity. The palmitoyl modification enhances its solubility within the skin's lipid environment, potentially improving dermal penetration.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Palmitoyl Tripeptide-36 exhibits antimicrobial activity at very low minimum inhibitory concentrations against Staphylococcus aureus and various fungi, damaging their cell membranes.

Transparency

Dusting Analysis

Not commonly dusted

No specific data regarding 'dusting' or minimal effective concentrations for TRIPEPTIDE-36 as a standalone cosmetic ingredient is available.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Peptides are generally susceptible to degradation, necessitating careful handling. Palmitoyl Tripeptide-36, being amphiphilic, benefits from the palmitoyl group which enhances its stability and lipid solubility within formulations. Optimal storage typically involves refrigeration, protection from light, and avoidance of freezing temperatures.

Synergies

  • Azelaic acid (for acne treatments)
  • Vitamins B3, B5, E (in active ingredient complexes for face care)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

TRIPEPTIDE-36 and its palmitoylated derivative have not been specifically reviewed by regulatory bodies like CIR, SCCS, or FDA. However, other well-studied related tripeptides (e.g., Tripeptide-1, Palmitoyl Tripeptide-1) are generally considered safe for cosmetic use at typical concentrations, often below 10 ppm. Toxicology assessments of certain GHK peptides also support their safety in cosmetics based on low use concentrations and negative findings for repeated dosage toxicity, skin irritation, sensitization, and genotoxicity.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While direct research on TRIPEPTIDE-36 is limited, its derivative, Palmitoyl Tripeptide-36, presents compelling evidence for antimicrobial and regenerative benefits, suggesting potential value if further specific research on TRIPEPTIDE-36 emerges.

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