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TRIMETHYLPYRAZINE.

Optional CAS 14667-55-1 / PERFUMING

Trimethylpyrazine is an organic compound primarily valued in the flavor and fragrance industries for its distinct roasty, nutty, and earthy aroma. In skincare formulations, its function is limited to imparting a specific scent profile, providing no direct therapeutic benefits to the skin.

Fragrance Ingredient

Science

On a dermatological level, Trimethylpyrazine does not actively interact with skin cells or biological pathways to induce therapeutic changes. Its mechanism in skincare is purely sensory, functioning as a fragrance enhancer to impart a characteristic aroma to products.


Research

Insufficient-data confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Both
Optimal pH N/A
0 7 14

Stability

This ingredient exhibits good stability and is non-discoloring in most media. For optimal integrity, storage away from highly reactive chemicals is recommended.

Conflicts

  • Highly reactive chemicals

Safety

CIR Status
Safe as used
Sensitization risk Low

The Expert Panel for Fragrance Safety (RIFM) has concluded that 2,3,5-trimethylpyrazine is safe at current usage levels in fragrance products. It is not identified as a skin sensitizer and is not anticipated to be photoirritating. While its photoallergenic potential is still under research, existing data suggests it is not genotoxic, and exposure levels fall below the Threshold of Toxicological Concern for various toxicities. However, safety data sheets indicate a potential for mild skin and eye irritation.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Optional

Trimethylpyrazine serves solely as a fragrance component in skincare, contributing no direct benefits to skin health or function, making its inclusion purely for sensorial appeal.


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