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TRIMETHYLHEXYL ACETATE.

Questionable CAS 58430-94-7 / PERFUMING

Trimethylhexyl acetate is an organic ester primarily valued in cosmetic formulations for its pleasant, fruity fragrance. Beyond its aromatic contribution, it also imparts emollient properties, which can improve skin feel and enhance formulation stability.

Fragrance Emollient

Science

This ingredient functions primarily as a fragrance, delivering a distinctive fruity aroma to products. Its emollient action contributes to a smoother skin texture and supports the overall stability and tactile quality of cosmetic formulations.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Trimethylhexyl acetate demonstrates stability under typical conditions but requires storage away from strong oxidizing agents. As an ester, it will react with acids to liberate heat alongside alcohols and acids, with strong oxidizing acids potentially causing a vigorous, exothermic reaction. Heat is also generated upon interaction with caustic solutions, and mixing with alkali metals or hydrides can generate flammable hydrogen gas.

Conflicts

  • strong oxidizing agents
  • strong acids
  • caustic solutions
  • alkali metals
  • hydrides

Safety

CIR Status
Insufficient data
Sensitization risk Moderate

The Research Institute for Fragrance Materials (RIFM) has completed a safety assessment for trimethylhexyl acetate concerning its use as a fragrance. However, the Cosmetic Ingredient Review (CIR) Panel is currently evaluating if this assessment is adequate for other cosmetic uses and exposures. An OECD 408, 90-day repeated dose toxicity study is planned to complete its ECHA REACH Dossier. It is classified with a GHS hazard statement H315, indicating it 'Causes skin irritation', and may also cause irritation to the skin and eyes upon direct contact.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Questionable

Given its classification as a skin irritant, ongoing safety evaluations, and primary role as a fragrance, Trimethylhexyl Acetate is a questionable inclusion for precision skincare formulations.


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