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Moumoujus

TRIMETHYLDODECATRIEN-3-YL ACETATE.

Insufficient Data CAS 2306-78-7 / PERFUMING

This ester, often identified as Nerolidyl Acetate, is widely utilized in fragrance applications. Beyond its aromatic qualities, research suggests it may offer antioxidant and anti-inflammatory benefits to the skin, with a related compound known for enhancing ingredient absorption.

Summary

Antioxidant Anti-inflammatory agent Antimicrobial agent Skin penetration enhancer Fragrance ingredient

Science

Mechanism of Action

Studies indicate that Nerolidyl Acetate possesses antioxidant capabilities, protecting cellular lipids, proteins, and DNA from oxidative stress. It also exhibits anti-inflammatory and antibacterial properties. A closely related compound, Nerolidol, is recognized for its ability to enhance the penetration of other active ingredients into the skin, alongside its own antimicrobial and anti-inflammatory effects.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH 4 – 8
0 7 14

Stability

As an ester, this compound is susceptible to hydrolysis when exposed to extreme acidic or alkaline conditions. However, it demonstrates stability within the typical cosmetic pH range of 4-8. Formulators should exercise caution in highly alkaline systems to maintain product integrity.

Conflicts

  • Strong acids
  • Strong alkalis

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
8%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has determined this ingredient, when referred to as Nerolidyl Acetate (isomer unspecified), is safe for use in fragrance concentrates up to 8%, and up to 5% for the (±)-isomer. Its safety in fragrance applications is typically assessed by the Research Institute for Fragrance Materials (RIFM), with human skin patch tests at 12% in petrolatum demonstrating no irritation or sensitization.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While primarily valued for its aromatic properties and deemed safe for restricted use, TRIMETHYLDODECATRIEN-3-YL ACETATE requires further direct clinical research to substantiate its preliminary reported skin benefits for precision skincare applications.

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